Anti-OX40L (OX-89)

Anti-OX40L [OX-89], Recombinant, IgG1 kappa, Rat
SKU
ABAAb00564-6.1
Packaging Unit
200 μg
Manufacturer
Absolute Antibody

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CloneID: OX-89

Antigen Long Description: This antibody was prepared by immunizing PVG rats with a recombinant chimeric protein consisting of domains 3 and 4 of rat CD4 and the extracellular region of mouse CD134L.

Buffer Composition: PBS with 0.02% Proclin 300.

Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7

Uniprot Accession No.: P43488

Specificity Statement: This antibody is specific for murine CD252 (the ligand for OX40), expression of which is restricted to activated B cells, dendritic cells, microglia and endothelial cells.

Application Notes (Clone): This antibody binds mouse CD134L, and has been shown to bind activated B cells and DCs, as well as CD134L-transfected fibroblast cells, though not activated T cells, in labelling and immunohistochemical analysis (Malmström, 2001). In addition, this antibody is able to partially block the interaction between CD134 and CD134L. This blocking effect could be responsible for the ability of this antibody to prevent T cell accumulation in the intestine of T cell-restored SCID mice and inhibits the development of Th1-mediated colitis.
More Information
SKU ABAAb00564-6.1
Manufacturer Absolute Antibody
Manufacturer SKU Ab00564-6.1
Package Unit 200 μg
Quantity Unit STK
Reactivity Mouse (Murine)
Clonality Recombinant
Application Immunohistochemistry (frozen), Flow Cytometry, Blocking
Isotype IgG1 kappa
Host Rat
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