Anti-PAI-1 (8H9D4)

Anti-PAI-1 [8H9D4], Recombinant, IgG1 kappa, Human
SKU
ABAAb03641-10.3-BT
Packaging Unit
1 mg
Manufacturer
Absolute Antibody

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CloneID: 8H9D4

Heavy Chain modification: Fc Silent™

Antigen Long Description: The original antibody was generated using PAI-1 complex as an immunogen.

Origin Pub PMID: 9161416

Buffer Composition: PBS only.

Chimeric Use Statement: This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Uniprot Accession No.: P05121

Specificity Statement: This antibody binds human PAI-1 at an epitope between amino acids 277 and 327, more particularly it binds residues between Arg300, Gln303 and Asp305 located on the loop between α-helix I and β-strand 5A. This antibody cross-reacts with pig PAI-1 but not with mouse or rat. Plasminogen activator inhibitor-1 (PAI-1), is a serine protease inhibitor, a unique member of the serpin superfamily which plays an important role in fibrinolysis and is an established risk factor for cardiovascular diseases. It a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading .

Application Notes (Clone): This antibody is reported to have strong inhibitory effect towards PAI-1 activity. The cross reactivity of this antibody towards other PAI-1 than human was done using ELISA (PMID: 9048903). This antibody shifts the reaction to the substrate pathway without decreasing the rate-limiting constant for reactive center loop insertion by tPA (PMID: 12223472). This antibody interferes with the final locking step in the serpin/proteinase interaction, thereby explaining its substrate inducing properties (PMID: 12871373).
More Information
SKU ABAAb03641-10.3-BT
Manufacturer Absolute Antibody
Manufacturer SKU Ab03641-10.3-BT
Package Unit 1 mg
Quantity Unit STK
Reactivity Human, Pig (Porcine)
Clonality Recombinant
Application ELISA, Neutralization, Inhibition
Isotype IgG1 kappa
Host Human
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