Anti-Quadruplex DNA (4E11)

Anti-Quadruplex DNA [4E11], Recombinant, IgG1 kappa, Mouse

CloneID: 4E11

Antigen Long Description: Oxy-2 or d(TTTTGGGG)2.

Buffer Composition: PBS only.

Chimeric Use Statement: This reformatted mouse antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.

Specificity Statement: The antibody binds to quadruplex DNA with a Kd of 2.64 nM. Binds specifically to only one type of quadruplex DNA, Oxy-2 (d(TTTTGGGG)2).

Application Notes (Clone): This antibody binds to quadruplex DNA, which is generated through the association of four guanines bound through Hoogsteen base pairing. G4-forming sequences are associated with immunoglobulin switch regions, promoter sequences, rDNA and telomeric repeats.

• SKU: ABAAb00390-1.1-BT
• Manufacturer: Absolute Antibody
• Manufacturer SKU: Ab00390-1.1-BT
• Package Unit: 1 mg
• Quantity Unit: STK
• Reactivity: Various species
• Clonality: Recombinant
• Application: ELISA, Immunohistochemistry
• Isotype: IgG1 kappa
• Host: Mouse