Anti-RANK-L (2G8)

Anti-RANK-L [2G8], Recombinant, IgG1 kappa, Human

CloneID: 2G8

Antigen Long Description: The original antibody was generated by panning a fully human Naive combined antibody library against RANKL.

Buffer Composition: PBS only.

Uniprot Accession No.: O14788

Specificity Statement: The antibody is specific for human-RANK-L. RANKL is a tumor necrosis factor (TNF)-related protein that binds to, and activates, the TNF receptor (TNFR)-related protein Receptor Activator of NF-kB (RANK). RANKL acts as the key cytokine that regulates osteoclast differentiation and activation during normal bone remodeling and during disease.

Application Notes (Clone): The affinity of the original format of the antibody was determined by Scatchard analysis; the results showed that the affinity of the antibody reached 3.2X10E-9. The specificity of the Fab version of the antibody was confirmed by ELISA analysis. The Fab fragment had a good neutralizing effect when tested in an antagonistic RANKL neutralization ability test (WO2009105934A1).

• SKU: ABAAb04141-10.0-BT
• Manufacturer: Absolute Antibody
• Manufacturer SKU: Ab04141-10.0-BT
• Package Unit: 1 mg
• Quantity Unit: STK
• Reactivity: Human
• Clonality: Recombinant
• Application: ELISA, Neutralization
• Isotype: IgG1 kappa
• Host: Human