Anti-RT1-D (OX-17)

Anti-RT1-D [OX-17], Recombinant, IgG2b kappa, Rat
SKU
ABAAb00582-8.4
Packaging Unit
200 μg
Manufacturer
Absolute Antibody

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CloneID: OX-17

Heavy Chain modification: Fc Silent™

Antigen Long Description: OX-17 was generated using BALB/c mice raised against rat spleen glycoproteins depleted of the Ia-A antigen using an OX-6 immunoaffinity column.

Buffer Composition: PBS with 0.02% Proclin 300.

Chimeric Use Statement: This chimeric rat antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7

Uniprot Accession No.: O98172

Specificity Statement: The OX-17 antigenic determinant is isotypic and on the alpha chain. OX-17 labels B but not T cells from lymph node or thoracic duct lymph but very weakly labels thymocytes and does not label erythrocytes. OX-17 does not cross-react with Rat Ia-A or Mouse Ia-E antigen. The target antigen is expressed on antigen presenting cells, including B cells, macrophages and dendritic cells. RT1-D is a rat MHC class II protein. RT1-D is equivalent to mouse I-E antigen.

Application Notes (Clone): This antibody binds to rat MHC Class I, and has been used to show that, in an in vivo rat model, antibodies against MHC class I antigens from stored blood may precipitate transfusion-related acute lung injury (Kelher, 2009).
More Information
SKU ABAAb00582-8.4
Manufacturer Absolute Antibody
Manufacturer SKU Ab00582-8.4
Package Unit 200 μg
Quantity Unit STK
Reactivity Rat (Rattus)
Clonality Recombinant
Application Immunofluorescence, Immunoprecipitation, Western Blotting, Flow Cytometry
Isotype IgG2b kappa
Host Rat
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