Anti-SIRP g (OX-119)

Anti-SIRP g [OX-119], Recombinant, IgG1 kappa, Mouse
SKU
ABAAb00589-1.1
Packaging Unit
200 μg
Manufacturer
Absolute Antibody

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CloneID: OX-119

Antigen Long Description: OX-119 was prepared by immunizing BALB/c mice with a chimeric protein made up of human SIRPg and a leader peptide of rat CD4 domain (SIRPg-CD4 ).

Buffer Composition: PBS with 0.02% Proclin 300.

Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7

Uniprot Accession No.: Q9P1W8

Specificity Statement: Hybridoma supernatants were initially screened by ELISA, using SIRPg-CD4, human SIRPa-Fc, human SIRPb-Fc or CD4 to eliminate hybridomas with cross-reactivity to rat CD4, human SIRPa, and SIRPb. There is some marginal binding of OX-119 to SIRPb transfected 293T cells. SIRPg binds CD47. On binding with CD47, mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation. Expressed on CD4+ T-cells, CD8+ T-cells, CD56-bright natural killer (NK) cells, CD20+ cells, and all activated NK cells..

Application Notes (Clone): OX-119 is able to perform staining of peripheral blood myeloid cells (PBMCs) and block SIRPg-mediated apoptosis. OX-119 can also be used in IP, FC and ELISA.
More Information
SKU ABAAb00589-1.1
Manufacturer Absolute Antibody
Manufacturer SKU Ab00589-1.1
Package Unit 200 μg
Quantity Unit STK
Reactivity Human
Clonality Recombinant
Application Immunoprecipitation, ELISA, Flow Cytometry, Blocking
Isotype IgG1 kappa
Host Mouse
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