CloneID: SL15S
Heavy Chain modification: ScFv
Antigen Long Description: The original antibody was generated by panning a human phage antibody library against TGF beta1.
Buffer Composition: PBS with 0.02% Proclin 300.
Chimeric Use Statement: This is a reformatted human scFv antibody, based on the original human scFv format, created for improved compatibility with existing reagents, assays and techniques.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: P01137
Specificity Statement: The antibody is specific for TGFβ2. It does not cross-react with TGFβ2 or TGFβ3.
Application Notes (Clone): The specificity of the original format of the antibody was confirmed by ELISA analysis. The ability of the scFv fragment to recognise TGFβ1 and neutralise binding of TGFβ1 to A549 cells was measured in the radioreceptor assay. The scFv fragment was a highly potent, neutralising antibody for TGFβ1, with IC50 values in the range 0.03 to 0 1 nM. In particular, the scFv fragment could neutralise active, but not latent, TGFβ1 (US7151169B2).
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