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Applications: Useful for the inhibition of TIGIT: CD155 and TIGIT: CD112 interactions in biochemical assays. For neutralizing TIGIT in cellular assays, we recommend cat. #71340
Assay Conditions: Antibody was added to TIGIT: CD155 or TIGIT: CD112 homogenous assays at various concentrations. Assay was performed according to the protocol in BPS Cat #72029 or #72023, respectively.
Description: Recombinant human TIGIT inhibitor antibody recognizing an epitope that prevents TIGIT interaction with CD155 on immune cells.
Format: Aqueous buffer solution
Formulation: 8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol.
Purification: Protein A affinity chromatography from HEK293 supernatants.
Storage Stability: Stable for at least 12 months at -80°C. Avoid freeze/thaw cycles. Store diluted antibody with carrier protein (BSA 0.1 - 0.5%) at 4°C, stable for 2 weeks.
Uniprot: Q495A1
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1.Yu, X., et al., Nat. Immunol. 2009; 10(1): 48-57.2.Stanietsky, N., et al., Proc. Natl. Acad. Sci. (USA). 2009; 106(42): 17858-17863.
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