CloneID: 679-14-E06
Heavy Chain modification: Fc Silent™
Antigen Long Description: Autoantigen TG2.
Buffer Composition: PBS with 0.02% Proclin 300.
Chimeric Use Statement: This chimeric mouse antibody was made using the variable domain sequences of the original Human IgA format, for improved compatibility with existing reagents, assays and techniques.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: P21980
Specificity Statement: The antibody binds to the N-terminal region of TG2 with a Kd of 55 nM.
Application Notes (Clone): This antibody binds to human Transglutaminase 2, an enzyme that catalyzes the isopeptide bond formation between an amine group and an acyl group at the end of the side chain of a glutamine. Anti-TG2 antibody are found in celiac disease and high levels of transglutaminase are found in Huntington's and Parkinson's.
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