Anti-VEGF (A.4.6.1)

Anti-VEGF [A.4.6.1], Recombinant, IgG1 kappa, Human
SKU
ABAAb00339-10.3
Packaging Unit
200 μg
Manufacturer
Absolute Antibody

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CloneID: A.4.6.1

Heavy Chain modification: Fc Silent™

Antigen Long Description: Recombinant human VEGF.

Origin Pub PMID: 9377574

Buffer Composition: PBS with 0.02% Proclin 300.

Chimeric Use Statement: This chimeric human antibody was made using the variable domain sequences of the original mouse IgG1 format for improved compatibility with existing reagents, assays and techniques.

Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7

Uniprot Accession No.: P15692

Specificity Statement: Binds native and reduced human VEGF (isoform 165), with a Kd of 0.8 nm determined for the original clone.

Application Notes (Clone): This is the parental antibody clone to the humanized, therapeutic antibody Bevacizumab (marketed as Avastin) binding to VEGF. VEGF is a growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. It induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels.
More Information
SKU ABAAb00339-10.3
Manufacturer Absolute Antibody
Manufacturer SKU Ab00339-10.3
Package Unit 200 μg
Quantity Unit STK
Reactivity Human, Rat (Rattus)
Clonality Recombinant
Application Immunoprecipitation, Western Blotting, ELISA, Flow Cytometry, Immunohistochemistry
Isotype IgG1 kappa
Host Human
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