Antihistamine-1, CAS 1186430-60-3

Product Description: Antihistamine-1 is a H1-antihistamine (Ki=6.9 nM) with acceptable blood-brain barrier penetration and also an inhibitor of CYP2D6 and hERG channel with IC50s of 5.4 and 0.8 μM, respectively.

Applications: Metabolism-sugar/lipid metabolism

Formula: C23H24FN5

References: [1]Lavrador-Erb K, et al. The discovery and structure-activity relationships of 2-(piperidin-3-yl)-1H-benzimidazoles as selective, CNS penetrating H1-antihistamines for insomnia. Bioorg Med Chem Lett. 2010 May 1;20(9):2916-9.

CAS Number: 1186430-60-3

Molecular Weight: 389.47

Compound Purity: 99.45

Research Area: Neurological Disease; Endocrinology

Solubility: DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C)

Target: Cytochrome P450;Histamine Receptor;Potassium Channel

• SKU: MEXHY-100238-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-100238-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK