AP20187, CAS 195514-80-8

Product Description: AP20187 (B/B Homodimerizer) is a cell-permeable ligand used to dimerize FK506-binding protein (FKBP) fusion proteins and initiate biological signaling cascades and gene expression or disrupt protein-protein interactions.

Applications: Metabolism-protein/nucleotide metabolism

Formula: C82H107N5O20

References: [1]Ahmed S, et al. Photocleavable dimerizer for the rapid reversal of molecular trap antagonists. J Biol Chem. 2014 Feb 21;289(8):4546-52./[2]Lin W, et al. Oligodendrocyte-specific activation of PERK signaling protects mice against experimental autoimmune encephalomyelitis. J Neurosci. 2013 Apr 3;33(14):5980-91./[3]Haas ME, et al. The Role of Proprotein Convertase Subtilisin/Kexin Type 9 in Nephrotic Syndrome-Associated Hypercholesterolemia. Circulation. 2016 Jul 5;134(1):61-72.

CAS Number: 195514-80-8

Molecular Weight: 1482.75

Compound Purity: 99.88

Research Area: Metabolic Disease

Solubility: DMSO : ≥ 57 mg/mL/Ethanol : ≥ 71.43 mg/mL

Target: FKBP

• SKU: MEXHY-13992-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-13992-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK