APE1-IN-1, CAS 524708-03-0

Product Description: APE1-IN-1 is a potent and blood-brain barrier (BBB) penetrant apurinic/apyrimidinic (AP) endonuclease 1 (APE1) inhibitor with an IC50 value of 2 μM. APE1-IN-1 can potentiate the cytotoxicity of the alkylating agents Methylmethane sulfonate and Temozolomide (HY-17364) to cancer cells[1].

Applications: Cancer-programmed cell death

Formula: C19H21N3OS2

References: [1]Rai G, et al. Synthesis, biological evaluation, and structure-activity relationships of a novel class of apurinic/apyrimidinic endonuclease 1 inhibitors. J Med Chem. 2012 Apr 12;55(7):3101-12.

CAS Number: 524708-03-0

Molecular Weight: 371.531

Compound Purity: 99.52

Research Area: Cancer

Solubility: DMSO : 10 mg/mL (ultrasonic;warming;heat to 60°C)

Target: DNA/RNA Synthesis

• SKU: MEXHY-136731-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-136731-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK