APY29, CAS 1216665-49-4

Product Description: APY29, an ATP-competitive inhibitor, is an allosteric modulator of IRE1α which inhibits IRE1α autophosphorylation by binding to the ATP-binding pocket with IC50 of 280 nM. APY29 acts as a ligand that allosterically activates IRE1α adjacent RNase domain[1].

Applications: Cancer-Kinase/protease

Formula: C17H16N8

References: [1]Wang L, et al. Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors. Nat Chem Biol. 2012 Dec;8(12):982-9.

CAS Number: 1216665-49-4

Molecular Weight: 332.36

Compound Purity: 99.90

Research Area: Cancer

Solubility: DMSO : 50 mg/mL (ultrasonic;warming;heat to 60°C)

Target: IRE1

• SKU: MEXHY-17537-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-17537-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK