Target: Aquaporin 1
Conjugate: HRP
Product Type: Polyclonal
Immunogen: Produced against the N-terminal peptide (sequence N-MASEFKKKLF) of rat Aquaporin 1
Swiss-Prot: P29975
Purification: Protein A Purified
Storage Buffer: 73.64mM Carbonate, 54.55mM Ethanolamine, 45.45mM Cyanoborohydride, 18.18mM Sodium Hydroxide and 0.23mM Citrate in dH2O
Concentration: 1 mg/ml
Specificity: Detects ~28.5kDa. May detect larger glycosylated bands ~35-50kDa.
Cellular Localization: Membrane
Scientific Background: Aquaporins selectively conduct water molecules in and out of the cell, while preventing the passage of ions and other solutes. Known as water channels, they are integral membrane pore proteins (1, 2). Aquarporin 1 is a widely expressed water channel, found in the basolateral and apical plasma membranes of the proximal tubes, the descending loop of Henel and in the descending portion of the vasa recta. Additionally it is found in red blood cells, vascular endothelium, gastrointestinal tract, sweat glands and lungs. It is not regulated by vasopressin (3).
References: 1. Gonen T., Walz T. (2006) Q. Rev. Biophys. 39(4): 361-396.2. Knepper M.A. (1994) Proc Natl. Acad Sci. USA. 91(14): 6255-6258.3. www.vivo.colostate.edu/hbooks/molecules/aquaporins.html
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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