ARCC-4, CAS 1973403-00-7

Product Description: ARCC-4 is a low-nanomolar Androgen Receptor (AR) degrader based on PROTAC, with a DC50 of 5?nM. ARCC-4 is an enzalutamide-based von Hippel-Lindau (VHL)-recruiting AR PROTAC and outperforms enzalutamide. ARCC-4 effectively degrades clinically relevant AR mutants associated with antiandrogen therapy[1].

Applications: Cancer-programmed cell death

Formula: C53H56F3N7O7S2

References: [1]Salami J, et al. Androgen receptor degradation by the proteolysis-targeting chimera ARCC-4 outperforms enzalutamide in cellular models of prostate cancer drug resistance. Commun Biol. 2018 Aug 2;1:100.

CAS Number: 1973403-00-7

Molecular Weight: 1024.18

Compound Purity: 99.88

Research Area: Cancer

Solubility: DMSO : 200 mg/mL (ultrasonic)

Target: Androgen Receptor;PROTACs

• SKU: MEXHY-130492-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-130492-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK