ARS-853, CAS 1629268-00-3

Product Description: ARS-853 is a cell-active, selective, covalent KRAS G12C inhibitor with an IC50 of 2.5 μM. ARS-853 inhibits mutant KRAS-driven signaling by binding to the GDP-bound oncoprotein and preventing activation[1][2].

Applications: Cancer-Kinase/protease

Formula: C22H29ClN4O3

References: [1]Lito P, et al. Allele-specific inhibitors inactivate mutant KRAS G12C by a trapping mechanism. Science. 2016 Feb 5;351(6273):604-8./[2]Patricelli MP, et al. Selective Inhibition of Oncogenic KRAS Output with Small Molecules Targeting the Inactive State. Cancer Discov. 2016 Mar;6(3):316-29.

CAS Number: 1629268-00-3

Molecular Weight: 432.94

Compound Purity: 98.39

Research Area: Cancer

Solubility: DMSO : 25 mg/mL (ultrasonic)

Target: Apoptosis;Ras

• SKU: MEXHY-19706-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-19706-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK