Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 3R-(3a,5aß,6ß,8aß,9a,10a,12ß,12aR)-decahydro-10-(methoxy-d3)-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C16H23D3O5
Formula Weight: 301.39282
CAS Number: 93787-85-0
Notes: Artemether-d3 is intended for use as an internal standard for the quantification of artemether (Item No. 11815) by GC- or LC-MS. Artemether is an antiparasitic agent and a derivative of artemisinin (Item No. 11816).{48487} It induces mortality in adult wild-type and pfatp6-mutant P. falciparum but the efficacy is decreased in the mutants (IC50s = 8.2 and 13.5 nM, respectively).{48485} Artemether reduces parasitemia in P. falciparum-infected monkeys and P. berghei-infected mice with 50% curative dose (CD50) values of 7.1 and 55 mg/kg, respectively.{48486} It also reduces the worm burden of S. mansoni trematodes in mice when used at doses ranging from 200 to 500 mg/kg.{48487} Formulations containing artemether have been used in the treatment of malaria.
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