Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 4-oxo-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)butanoic-2,2,3,3-d4 acid
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C19H24D4O8
Formula Weight: 388.5
CAS Number: 1316753-15-7
Notes: Artesunate-d4 is intended for use as an internal standard for the quantification of artesunate (Item No. 11817) by GC- or LC-MS. Artesunate is a derivative of artemisinin (Item No. 11816) that is active against P. falciparum in vitro (IC50 = 1.28 nM).{21232} It is an iron(II) oxide-reactive endoperoxide that generates reactive oxygen species (ROS) upon cleavage of its endoperoxide bridge.{35319} It inhibits the activity of the P. falciparum EXP1, a glutathione S-transferase (GST) that degrades hematin, with an IC50 value of 2.05 nM.{57853} Artesunate inhibits proliferation of germinal center B cells in vitro and prevents development of arthritis via inhibition of germinal center formation and autoantibody production in the K/BxN mouse model of rheumatoid arthritis when administered at a dose of 100 mg/kg twice per day.{42468} It also inhibits alveolitis and pulmonary fibrosis induced by bleomycin (Item No. 13877) in rats.{42469} Artesunate increases the activity of GST in mice infected with P. berghei compared to uninfected and infected control animals.{57854}
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