Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: (SP-5-22)-trichloro[1,2-ethanediolato(2-)-?O1,?O2]-tellurate(1-), monoammonium salt
Purity: ≥95%
Formula Markup: C2H4Cl3O2Te / NH4
Formula Weight: 312.0
CAS Number: 106566-58-9
Notes: AS-101 is an immunomodulator.{36943} It inhibits IL-10 secretion from and cell proliferation of IL-10-secreting human stomach adenocarcinoma and glioblastoma multiforme (GBM) cells when used at concentrations ranging from 0.5 to 2.5 µg/ml, an effect that can be blocked by the addition of recombinant IL-10. It reverses IL-10-induced increases in phosphorylated Stat3 and reduces the expression of Bcl-2 in B16 murine melanoma cells. AS-101 sensitizes GBM cells to paclitaxel (Item No. 10461), doxorubicin (Item No. 15007), and 5-fluorouracil (5-FU; Item No. 14416) in vitro and to paclitaxel in a GBM mouse xenograft model when administered at a dose of 0.5 mg/kg per day. AS-101 (1 mg/kg) also prevents infiltration of CD49d+ cells and decreases the expression of IL-6, TNF-α, IL-1β, and MCP-1 in the spinal cord, as well as delays onset and slows the progression of symptoms in a mouse model of experimental autoimmune encephalomyelitis (EAE).{36944}
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