AS-605240 (potassium)

Product Description: AS-605240 (potassium) is an orally active PI3Kγ inhibitor (IC50: 8 nM; Ki: 7.8 nM). AS-605240 (potassium) inhibits MCP-1- and CSF1-induced PKB phosphorylation (IC50 values are 0.181 and 0.550 µM, respectively). AS-605240 (potassium) reduces neutrophil recruitment in RANTES (CCL5)- and thioglycolate-induced peritonitis mouse models (EC50 values are 9.1 and 10 mg/kg, respectively). AS-605240 (potassium) ameliorates αCII-IA-induced arthritis in mice[1].

Formula: C12H6KN3O2S

References: [1]Camps M, et al. Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis. Nat Med. 2005 Sep;11(9):936-43.

Molecular Weight: 295.36

Research Area: Inflammation/Immunology

Target: Akt;PI3K

• SKU: MEXHY-10109A-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-10109A-0
• Package Unit: Get quote
• Quantity Unit: STK