Product Description: AS1842856, a specific Foxo1 inhibitor (IC50=30 nM), potently suppresses autophagy[1]. AS1842856 reduces Foxo1 activity and, to a lesser extent, inhibits Foxo1 protein expression by simply binding to Foxo1[2].
Applications: Metabolism-sugar/lipid metabolism
Formula: C18H22FN3O3
References: [1]Nagashima T, et al. Discovery of novel forkhead box O1 inhibitors for treating type 2 diabetes: improvement of fasting glycemia in diabetic db/db mice. Mol Pharmacol. 2010 Nov;78(5):961-70./[2]He J, et al. The resistant effect of SIRT1 in oxidative stress-induced senescence of rat nucleus pulposus cell is regulated by Akt-FoxO1 pathway. Biosci Rep. 2019 May 10;39(5). pii: BSR20190112.
CAS Number: 836620-48-5
Molecular Weight: 347.38
Compound Purity: 99.88
Research Area: Metabolic Disease
Solubility: DMSO : 5 mg/mL (ultrasonic;warming;heat to 60°C)
Target: Autophagy
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