ASLAN003, CAS 1035688-66-4

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 2-[(3,5-difluoro-3'-methoxy[1,1'-biphenyl]-4-yl)amino]-3-pyridinecarboxylic acid

Purity: ≥98%

Formula Markup: C19H14F2N2O3

Formula Weight: 356.322946

CAS Number: 1035688-66-4

Notes: ASLAN003 is an inhibitor of dihydroorotate dehydrogenase (DHODH; IC50 = 35 nM).{57586} It inhibits the proliferation of MOLM-14 and KG-1 acute myeloid leukemia (AML) cells (IC50s = 0.582 and 0.382 µM, respectively), as well as induces apoptosis in the same cells when used at concentrations of 0.5 and 1 µM. ASLAN003 (1, 2, and 4 µM) induces differentiation in bone marrow cells isolated from patients with AML or myelodysplastic syndrome (MDS). It improves survival in a patient-derived xenograft (PDX) mouse model of AML when administered at a dose of 50 mg/kg.

• SKU: CAY33516-50
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 33516-50
• Package Unit: 50 mg
• Quantity Unit: STK