Product Description: Asundexian (BAY 2433334) is an orally active coagulation factor Xia (FXIa) inhibitor. Asundexian binds directly, potently, and reversibly to the active site of FXIa and thereby inhibits its activity. Asundexian inhibits human FXIa in buffer with an IC50 of 1 nM[1].
Applications: Neuroscience-Neuromodulation
Formula: C26H21ClF4N6O4
References: [1]Thomas D, et al. First evaluation of the safety, pharmacokinetics, and pharmacodynamics of BAY 2433334, a small molecule targeting coagulation factor XIa. J Thromb Haemost. 2021;19(10):2407-2416.
CAS Number: 2064121-65-7
Molecular Weight: 592.93
Compound Purity: 99.93
Research Area: Cardiovascular Disease
Solubility: DMSO : ≥ 250 mg/mL
Target: Factor Xa