AT1R antagonist 3, CAS 3053482-15-5

Product Description: AT1R antagonist 3 (Compound 1) is an antagonist for angiotensin II type 1 receptor (AT1R) and an inhibitor for calcium channel type-L CaV1.2 (IC50=0.57 μM). AT1R antagonist 3 exhibits vasodilation efficacy in solated rat aorta (10 μM, 88.7%) and antihypertensive efficacy in rat models[1].

Formula: C22H16N6O2S

References: [1]Gutiérrez-Hernández A, et al., Synthesis, biosimulation and pharmacological evaluation of benzimidazole derivatives with antihypertensive multitarget effect. Bioorg Med Chem Lett. 2024 Jul 6;110:129879.

Molecular Weight: 428.47

Research Area: Cardiovascular Disease

Target: Angiotensin Receptor;Calcium Channel

• SKU: MEXHY-159090-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-159090-0
• Package Unit: Get quote
• Quantity Unit: STK