AT7519 (hydrochloride), CAS 902135-91-5

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 4-[(2,6-dichlorobenzoyl)amino]-N-4-piperidinyl-1H-pyrazole-3-carboxamide, monohydrochloride

Purity: ≥98%

Formula Markup: C16H17Cl2N5O2 / HCl

Formula Weight: 418.7

CAS Number: 902135-91-5

Notes: AT7519 is an ATP-competitive inhibitor of cyclin-dependent kinases (Cdks) with IC50 values of 210, 47, 100, 13, 170, and 50 = 89 nM).{30113} AT7519 demonstrates antiproliferative activity against a wide variety of human tumor cell lines (IC50s = 40-940 nM in vitro), inhibiting cell cycle progression and inducing apoptosis, and prevents tumor growth in human tumor xenograft models.{30113,30112} AT7519 induces activation of GSK3β by down-regulating GSK3β phosphorylation, which contributes to AT7519-induced apoptosis.{30112}

• SKU: CAY16231-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 16231-5
• Package Unit: 5 mg
• Quantity Unit: STK