Target: ATF4
Conjugate: RPE
Product Type: Monoclonal
Clone Number: N360A/24 (Formerly sold as S360A-24)
Immunogen: Fusion protein amino acids 25-327 of human ATF4. 86% identical to rat, and 85% identical to mouse. <50% identity with ATF5.
Swiss-Prot: P18848
Purification: Protein G Purified
Storage Buffer: 95.64mM Phosphate, 2.48mM MES and 2mM EDTA
Concentration: 1 mg/ml
Specificity: Detects ~60kDa. Does not cross-react with ATF5.
Cellular Localization: Cytoplasm / Cell Membrane / Nucleus
Scientific Background: Cyclic AMP-dependent transcription factor ATF-4 (ATF4) is a basic leucine-zipper (bZip) transcription factor, which regulates amino acid metabolism, DNA damage repair, chromatin remodeling, and apoptosis in response to cellular and ER stress. ATF4 works with various proteins, such as C/EBP homology protein (CHOP), aspargine synthetase (ASNS), and cAMP response element (CRE) among others to mediate cellular stress. ATF4 also regulates glucose homeostasis by suppressing beta-cell proliferation and insulin production. Furthermore, ATF4 targets the histone demethylase JMJD3 to alter chromatin structure and enhance gene transcription in response to amino acid deprivation.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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