Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: (4aS,8aR,9aS)-4a,5,6,7,8,8a,9,9a-octahydro-9a-hydroxy-3,8a-dimethyl-5-methylene-naphtho[2,3-b]furan-2(4H)-one
Purity: ≥98%
Formula Markup: C15H20O3
Formula Weight: 248.3175
CAS Number: 73030-71-4
Notes: Atractylenolide III is a sesquiterpene that has been isolated from Atractylodes and has diverse biological activities, including anti-inflammatory, anti-angiogenic, pro- and anti-apoptotic, and neuroprotective properties.{37638,37639,37640,37641,37642} It inhibits the release of nitric oxide (NO), prostaglandin E2 (PGE2; Item No. 14010), TNF-α, and IL-6 induced by LPS from RAW264.7 macrophages when used at a concentration of 50 µM.{37638} Atractylenolide III (100 µM) induces apoptosis and cell cycle arrest, as well as increases caspase-3, caspase-9, and poly(ADP-ribose) polymerase (PARP) cleavage in A549 human lung carcinoma cells.{37640} However, in primary embryonic mouse cerebral cortical neurons, it inhibits glutamate-induced apoptosis and DNA fragmentation when used at a concentration of 40 µM.{37641} It inhibits angiogenesis in an MDA-MB-231 human breast cancer mouse xenograft model when administered at a dose of 25 mg/kg per day.{37639} Atractylenolide III (0.6 mg/kg per day) also decreases the latency to find the platform in the Morris water maze in a rat model of learning deficits induced by high-dose homocysteine.{37642}
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