Product Description: AU1235, an adamantyl urea, is a potent MmpL3 inhibitor. The Mycobacterium tuberculosis protein MmpL3 performs an essential role in cell wall synthesis, since it effects the transport of trehalose monomycolates across the inner membrane[1][2].
Applications: Cancer-programmed cell death
Formula: C17H19F3N2O
References: [1]McNeil MB, et al. Multiple Mutations in Mycobacterium tuberculosis MmpL3 Increase Resistance to MmpL3 Inhibitors. mSphere. 2020;5(5):e00985-20. Published 2020 Oct 14./[2]Grzegorzewicz AE, et al. Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane. Nat Chem Biol. 2012;8(4):334-341. Published 2012 Feb 19.
CAS Number: 1338780-86-1
Molecular Weight: 324.34
Compound Purity: 99.90
Research Area: Cancer; Infection
Solubility: DMSO : 25 mg/mL (ultrasonic)
Target: Bacterial
English
Deutsch
