Description: Aurintricarboxylic acid (NSC-4056) is a strong inhibitor of topoisomerases and other nucleases. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme.
CAS Number: 4431-00-9
Formula: C22H14O9
Molecular Weight: 422,34
References: Liu T T , Yang T , Gao M N , et al. The inhibitory mechanism of aurintricarboxylic acid targeting serine/threonine phosphatase Stp1 in Staphylococcus aureus: insights from molecular dynamics simulations[J]. Acta Pharmacologica Sinica, 2019.