Autophinib, CAS 1644443-47-9

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 6-chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)-4-pyrimidinamine

Purity: ≥98%

Formula Markup: C14H11ClN6O3

Formula Weight: 346.72848

CAS Number: 1644443-47-9

Notes: Autophinib is an ATP-competitive inhibitor of the PI3K VPS34 (IC50 = 19 nM).{49061} It inhibits autophagy induced by the mTOR inhibitor rapamycin (Item No. 13346) or by amino acid starvation (IC50s = 40 and 90 nM, respectively) in MCF-7 cells. Autophinib also induces apoptosis in amino acid-starved MCF-7 cells with an EC50 value of 234 nM.

• SKU: CAY27320-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 27320-5
• Package Unit: 5 mg
• Quantity Unit: STK