Autophinib, CAS 1644443-47-9

Product Description: Autophinib is a potent, selective autophagy inhibitor with IC50s of 90 nM and 40 nM for starvation- and Rapamycin-induced autophagy, respectively. Autophinib is also an ATP competitive Vacuolar Protein Sorting 34 (VPS34) inhibitor with an IC50 of 19 nM. Autophinib inhibits autophagy induced by starvation or Rapamycin by targeting VPS34[1].

Applications: Cancer-programmed cell death

Formula: C14H11ClN6O3

References: [1]Robke L, et al. Phenotypic Identification of a Novel Autophagy Inhibitor Chemotype Targeting Lipid Kinase VPS34. Angew Chem Int Ed Engl. 2017 Jul 3;56(28):8153-8157.

CAS Number: 1644443-47-9

Molecular Weight: 346.73

Compound Purity: 99.95

Research Area: Cancer; Neurological Disease

Solubility: DMSO : 6.67 mg/mL (ultrasonic;warming;heat to 60°C)

Target: Autophagy;PI3K

• SKU: MEXHY-101920-25
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-101920-25
• Package Unit: 25 mg
• Quantity Unit: STK