Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: N-[(1S)-1-[3-[[[[3-methoxy-4-(5-oxazolyl)phenyl]amino]carbonyl]amino]phenyl]ethyl]-carbamic acid, (1R)-1-(cyanomethyl)propyl ester
Purity: ≥98%
Formula Markup: C25H27N5O5
Formula Weight: 477.5
CAS Number: 297730-17-7
Notes: AVN-944 is a selective, noncompetitive inhibitor of inosine-5'-monophosphate dehydrogenase (IMPDH; Ki = 6-10 nM for both human IMPDH isoforms), a rate-limiting enzyme involved in the de novo synthesis of purine nucleotides.{33492} Inhibition of IMPDH results in disruption of DNA and RNA synthesis, inhibition of cell proliferation, and the induction of apoptosis. AVN-944 has been shown to inhibit the proliferation of multiple myeloma cells in vitro by inducing caspase-independent apoptosis.{33492} It is also reported to have antitumor properties in androgen-sensitive and androgen-independent prostate cancer cells in vitro.{33491}
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