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CAS Number: 319460-85-0
Description: Axitinib (AG-013736) is an oral, potent, and selective inhibitor of vascular endothelial growth factor receptors 1 (VEGFR-1), 2 (VEGFR-2), and 3 (VEGFR-3), platelet derived growth factor receptor (PDGFR), and cKIT (CD117).
Format: White to off-white solid
Purity: ≥99%
Solubility: Soluble in DMSO at 33 mg/ml; soluble in ethanol at 1.7 mg/ml with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-50 µM.
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Biosafety Level: Not applicable (BSL-1)
References: Mancuso, M.R., et al. J. Clin. Invest. 116: 2610-2621 (2006).
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