AZ194, CAS 2241651-99-8

Product Description: AZ194 is a first-in-class, orally active inhibitor of CRMP2-Ubc9 interaction and inhibitor of NaV1.7 (IC50=1.2 μM). AZ194 blocks SUMOylation of CRMP2 to selectively reduce the amount of surface-expressed NaV1.7. Antinociceptive effects[1].

Applications: Neuroscience-Neuromodulation

Formula: C34H31F2N3O3

References: [1]Cai S, et al. Selective targeting of NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces pain in rodents. Sci Transl Med. 2021;13(619):eabh1314.

CAS Number: 2241651-99-8

Molecular Weight: 567.63

Compound Purity: 99.83

Research Area: Neurological Disease

Solubility: DMSO : 33.33 mg/mL (ultrasonic)

Target: Sodium Channel

• SKU: MEXHY-145169-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-145169-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK