AZ3146, CAS 1124329-14-1

Product Description: AZ3146 is a reasonably potent Mps1 and TTK inhibitor, with IC50 of 35 nM for Mps1Cat.

Applications: Cancer-Kinase/protease

Formula: C24H32N6O3

References: [1]Hewitt L, et al. Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1-C-Mad2 core complex. J Cell Biol. 2010 Jul 12;190(1):25-34./[2]Liu X, et al. TTK activates Akt and promotes proliferation and migration of hepatocellular carcinoma cells. Oncotarget. 2015 Oct 27;6(33):34309-20./[3]Gurden MD, et al. Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance. Cancer Res. 2015 Aug 15;75(16):3340-54.

CAS Number: 1124329-14-1

Molecular Weight: 452.55

Compound Purity: 99.92

Research Area: Cancer

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: Mps1

• SKU: MEXHY-14710-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-14710-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK