AZD 0095, CAS 2750001-23-9

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 2,5,7-trimethyl-6-[[(3R)-1-[4-[6-(4-morpholinylmethyl)-3-pyridazinyl]phenyl]-3-pyrrolidinyl]oxy]-[1,2,4]triazolo[1,5-a]pyrimidine

Purity: ≥98%

Formula Markup: C27H32N8O2

Formula Weight: 500.6

CAS Number: 2750001-23-9

Notes: An MCT4 inhibitor (IC50 = 1.3 nM); selectively inhibits lactate influx in NCI H358 cells (IC50 = 6.1 nM), which highly express MCT4 and do not express MCT1, over lactate influx in K562 cells (IC50 = >30 µM), which highly express MCT1 and do not express MCT4; inhibits the proliferation of NCI H358 cells (IC50 = 26 nM); reduces tumor growth in an NCI H358 mouse xenograft model at 100 mg/kg twice per day in combination with cediranib

• SKU: CAY42134-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 42134-10
• Package Unit: 10 mg
• Quantity Unit: STK