AZD 3229, CAS 2248003-60-1

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: N-[4-[[5-fluoro-7-(2-methoxyethoxy)-4-quinazolinyl]amino]phenyl]-4-(1-methylethyl)-1H-1,2,3-triazole-1-acetamide

Purity: ≥98%

Formula Markup: C24H26FN7O3

Formula Weight: 479.507023

CAS Number: 2248003-60-1

Notes: AZD 3229 is an inhibitor of c-Kit-driven cell proliferation.{51097} It selectively inhibits growth of c-Kit mutant (GI50s = 1-971 nM) and PDGFR mutant (GI50s = 1-22 nM) Ba/F3 cell lines over Ba/F3 cell lines expressing Tel-KDR/VEGFR2 (GI50 = 1,378 nM). AZD 3229 (20 mg/kg twice per day) induces tumor regression in a Ba/F3 mouse xenograft model and a mouse allograft model using Ba/F3 cells expressing KIT-exon 11 del/V654A, a common mutation in gastrointestinal stromal tumors (GIST).

• SKU: CAY27908-500
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 27908-500
• Package Unit: 500 µg
• Quantity Unit: STK