AZD 3463, CAS 1356962-20-3

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: N-[4-(4-amino-1-piperidinyl)-2-methoxyphenyl]-5-chloro-4-(1H-indol-3-yl)-2-pyrimidinamine

Purity: ≥98%

Formula Markup: C24H25ClN6O

Formula Weight: 449.0

CAS Number: 1356962-20-3

Notes: AZD 3463 is an inhibitor of anaplastic lymphoma kinase (ALK) and the insulin growth factor-1 receptor (IGF-1R).{43620} It inhibits ALK with an IC50 value of 15 nM.{38680} It inhibits the proliferation of neuroblastoma cells with wild-type (WT) ALK (IC50s = 2.8-21.3 µM) and ALK with the activating mutations ALKF1174L and ALKD1091N (IC50s = 1.7 and 16.49 µM, respectively) and induces apoptosis and autophagy.{43620} It reduces tumor growth in neuroblastoma mouse xenograft models expressing WT ALK or the ALKF1174L mutation when administered at a dose of 15 mg/kg per day for 21 days.

• SKU: CAY26172-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 26172-1
• Package Unit: 1 mg
• Quantity Unit: STK