AZD 7648, CAS 2230820-11-6

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 7,9-dihydro-7-methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-8H-purin-8-one

Purity: ≥98%

Formula Markup: C18H20N8O2

Formula Weight: 380.40412

CAS Number: 2230820-11-6

Notes: AZD 7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK; IC50 = 0.63 nM in an enzyme assay).{48616} It is selective for DNA-PK over TTK (IC50 = 5.012 μM), as well as JAK1, JAK2, JAK3, Aurora A, and Aurora B (IC50s = >10 μM for all). AZD 7648 reduces tumor growth in a FaDu ATM KO pharynx cancer mouse xenograft model when administered at doses of 37.5 or 75 mg/kg twice per day and induces tumor regression at these doses when administered in combination with the PARP inhibitor olaparib (Item No. 10621).

• SKU: CAY28598-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 28598-10
• Package Unit: 10 mg
• Quantity Unit: STK