Product Description: β-Glucogallin is an orally active and selective aldose reductase (AKR1B1) inhibitor with an IC50 value of 58 μM when using Glyceraldehyde (HY-128748) as AKR1B1 substrate. β-Glucogallin reduces ROS, PDGF, RAGE, and NF-κB. β-Glucogallin increases SOD. β-Glucogallin has antioxidant and hepatoprotective effects. β-Glucogallin can be used in retinal research[1][2][3][4][5].
Applications: Metabolism-sugar/lipid metabolism
Formula: C13H16O10
References: [1]Li L, et al. Design of an amide N-glycoside derivative of β-glucogallin: a stable, potent, and specific inhibitor of aldose reductase. J Med Chem. 2014 Jan 9;57(1):71-7./[2]Ma Y, Liu F, Xu Y. Protective Effect of β-Glucogallin on Damaged Cataract Against Methylglyoxal Induced Oxidative Stress in Cultured Lens Epithelial Cells. Med Sci Monit. 2019 Dec 7;25:9310-9318. /[3]Puppala M, Ponder J, Suryanarayana P, Reddy GB, Petrash JM, LaBarbera DV. The isolation and characterization of β-glucogallin as a novel aldose reductase inhibitor from Emblica officinalis. PLoS One. 2012;7(4):e31399./[4]Li L, Chang KC, Zhou Y, Shieh B, Ponder J, Abraham AD, Ali H, Snow A, Petrash JM, LaBarbera DV. Design of an amide N-glycoside derivative of β-glucogallin: a stable, potent, and specific inhibitor of aldose reductase. J Med Chem. 2014 Jan 9;57(1):71-7./[5]Majeed M, et al. Amelioration of carbon tetrachloride induced hepatotoxicity by Β-glucogallin, a gallic acid derivative of emblica officinalis gaertn.(euphorbiaceae). Science, 2015, 4(7): 696-701.
CAS Number: 13405-60-2
Molecular Weight: 332.26
Compound Purity: 99.82
Research Area: Metabolic Disease; Neurological Disease
Solubility: DMSO : 100 mg/mL (ultrasonic)/H2O : 6.25 mg/mL (ultrasonic)
Target: Aldose Reductase;NF-κB;PDGFR;Reactive Oxygen Species;SOD
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