Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 3-(methylamino)-L-alanine, monohydrochloride
Purity: ≥95%
Formula Markup: C4H10N2O2 / HCl
Formula Weight: 154.59512
CAS Number: 16012-55-8
Notes: β-Methylamino-L-alanine (BMAA) is a neurotoxic non-proteinogenic amino acid that has been found in cyanobacteria.{59025,59026} It is cytotoxic to mouse primary cortical neurons when used at a concentration of 3 mM in the presence of bicarbonate, an effect that can be blocked by the NMDA receptor antagonist MK-801 or the mGluR5 receptor antagonist MPEP (Item No. 14536).{59027} BMAA (3 mM) stimulates release of glutamate and induces oxidative stress in the same cells.{59028} It also enhances neuronal cell death induced by amyloid-β (25-35) in mouse primary cortical neurons when used at a concentration of 0.1 mM.{59027} Intracerebroventricular administration of BMAA (500 µg/animal) induces wet-dog shakes, rigidity, and clonic convulsions in rats.{59029} It induces parkinsonism in cynomolgus monkeys.{59030} BMAA has been found in commercial seafood.{59031}
English
Deutsch
