Products from BPS Bioscience require a minimum order value above 400€
Applications: Useful for studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications.
Description: Bace1 (β-secretase 1) is an aspartic protease that is involved in the processing of the Amyloid precursor protein (APP). Cleavage of APP by BACE1 followed by γ-secretase results in β-amyloid peptide production, which ultimately leads toxic Aβ accumulation. In Alzheimer's disease (AD), it has been widely accepted that Aβ aggregation plays a critical role in AD pathogenesis, suggesting that BACE1 could be a potential target to treat AD. The BACE1 FRET Assay Kit is designed to measure BACE1 activity for screening and profiling applications based on fluorescence resonance energy transfer (FRET) using a labeled peptide substrate (below).
Storage Stability: At least 12 months from date of receipt, when stored as directed. Kit components require different storage conditions. Be sure to store each component at the proper temperature upon arrival.
Supplied As: The BACE1 FRET Assay Kit comes in a convenient 96-well format, with enough purified recombinant human BACE1 enzyme, BACE1 FRET peptide substrate, and assay buffer for 100 enzyme reactions.
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: Ghosh, A.K., et al. J. Neurochemistry 120(suppl. 1):71-83 (2012)
English
Deutsch
