Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 3-[[4-(1,1-dimethylethyl)phenyl]sulfonyl]-2E-propenenitrile
Purity: ≥98%
Formula Markup: C13H15NO2S
Formula Weight: 249.3
CAS Number: 196309-76-9
Notes: In the classical pathway of NF-κB activation, phosphorylation of the inhibitor of NF-κB (IκBα) releases the inhibitor from NF-κB, allowing IκBα degradation and NF-κB activation and nuclear import.{19822} BAY 11-7085 is an irreversible inhibitor of IκBα phosphorylation, preventing activation of NF-κB by cytokines and lipopolysaccharide (IC50 = 10 μM).{16037} It blocks gene expression that is regulated through the classical pathway of NF-κB activation and in this way blocks apoptosis, cell adhesion, and inflammation.{16037,24580,24840} BAY 11-7085 is also used to study IκBα actions that are independent of NF-κB signaling.{24581}
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