Shelf life (days): 1460.0
Formulation: A solid
Formal Name: N-[5-(3,5-dicyano-1,4-dihydro-1,2,6-trimethyl-4-pyridinyl)-6-fluoro-7-methyl-1H-indazol-3-yl]-2-ethyl-benzamide
Purity: ≥98%
Formula Markup: C27H25FN6O
Formula Weight: 468.5
CAS Number: 2377576-35-5
Notes: BAY-3827 is an inhibitor of AMP-activated protein kinase (AMPK; IC50 = 1.4 nM at 10 µM ATP).{68892} It is selective for AMPK over Aurora A kinase, FMS-related tyrosine kinase 3 (FLT3), and c-Met (IC50s = 1,324, 124, and 788 nM, respectively), p90 ribosomal S6 kinase 2 (RSK2), RSK3, RSK4, p90 ribosomal S6 kinase 1 (MSK1), and MST3 (IC50s = 52, 36, 24, 43, and 94 nM, respectively), and a panel of 331 kinases at 10 µM but does inhibit RSK1 (IC50 = 9 nM). BAY-3827 selectively inhibits the proliferation of androgen-dependent LNCaP, VCaP, and 22Rv1 prostate cancer cells (IC50s = 0.28, 1.71, and 5.55 µM, respectively) over androgen receptor-negative C4-2B, PC3, and DU145 prostate cancer cells (IC50s = >10 µM for all).
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