Product Description: BAY-598 is selective small molecule inhibitor of SMYD2 with an IC50 of 27 nM[1][2].
Applications: Cancer-programmed cell death
Formula: C22H20Cl2F2N6O3
References: [1]Reynoird N, et al. Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreaticcancer. Genes Dev. 2016 Apr 1;30(7):772-85./[2]Eggert E, et al. Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in Vivo Probe (BAY-598) for the Protein Lysine Methyltransferase SMYD2. J Med Chem. 2016 May 26;59(10):4578-600.