Bazedoxifene (acetate), CAS 198481-33-3

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 1-[[4-[2-(hexahydro-1H-azepin-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol, acetate

Purity: ≥98%

Formula Markup: C30H34N2O3 / C2H4O2

Formula Weight: 530.7

CAS Number: 198481-33-3

Notes: Bazedoxifene (acetate) is a third generation selective estrogen receptor modulator (SERM). It is an indole-based ER ligand that binds to both ERα (IC50 = 26 nM) and ERβ (IC50 = 99 nM).{22645} Bazedoxifene (actetate) antagonizes 17β-estradiol-dependent MCF-7 and T47D breast cancer cell proliferation in vitro as well as hormone-independent growth of MCF-7:5C cells that are resistant to long-term estrogen deprivation (80% reduction with 10 nM).{22646} It has been shown to arrest cell cycling by downregulating cyclin D1 and ERα.{22646}

• SKU: CAY15005-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 15005-10
• Package Unit: 10 mg
• Quantity Unit: STK