Product Description: BCI ((E)-BCI) is a DUSP6 (dual specificity phosphatase 6) inhibitor. BCI shows anti-inflammatory activity and decreases reactive oxygen species (ROS) production. BCI can be used in inflammatory disease research[1][2].
Applications: Cancer-programmed cell death
Formula: C22H23NO
Citations: bioRxiv. 2024 Feb 5./Cells. 2022 Feb 19;11(4):732./Dis Model Mech. 2023 May 1;16(5):dmm049662./Int Immunopharmacol. 2024 Sep 30;143(Pt 1):113280./Kaohsiung J Med Sci. 2022 Dec 16./Neural Regen Res. 2023./Cancer Med. 2024 Oct;13(19):e70276./Cancers (Basel). 2023 Sep 6, 15(18), 4442./Development. 2023 Feb 13;dev.201090./Phytother Res. 2023 Mar 3.
References: [1]Korotchenko VN, et al. In vivo structure-activity relationship studies support allosteric targeting of a dual specificity phosphatase. Chembiochem. 2014 Jul 7;15(10):1436-45./[2]Zhang F, et al. DUSP6 Inhibitor (E/Z)-BCI Hydrochloride Attenuates Lipopolysaccharide-Induced Inflammatory Responses in Murine Macrophage Cells via Activating the Nrf2 Signaling Axis and Inhibiting the NF-κB Pathway. Inflammation. 2019 Apr;42(2):672-681.
CAS Number: 1245792-51-1
Molecular Weight: 317.43
Compound Purity: 99.73
Research Area: Inflammation/Immunology
Solubility: DMSO : 125 mg/mL (ultrasonic)
Target: Phosphatase
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