Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: (2E)-N-hydroxy-3-[3-[(phenylamino)sulfonyl]phenyl]-2-propenamide
Purity: ≥98%
Formula Markup: C15H14N2O4S
Formula Weight: 318.34874
CAS Number: 866323-14-0
Notes: Belinostat is an inhibitor of class I histone deacetylases (HDACs; IC50s = 0.041, 0.125, 0.03, and 0.216 µM for HDAC1, -2, -3, and -8, respectively) and class II HDACs (IC50s = 0.115, 0.082, 0.067, and 0.128 µM for HDAC4, -6, -7, and -9, respectively).{62263} It inhibits HDAC activity in HeLa cell lysates (IC50 = 0.027 µM) and the proliferation of A2780 ovarian, HCT116 colon, Calu-3 lung, and Hs 852.T melanoma cells (IC50s = 0.2, 0.2, 0.66, and 3.37 µM, respectively).{11585} It reduces tumor growth in an A2780 mouse xenograft model when administered at doses of 10, 20, and 40 mg/kg. Formulations containing belinostat have been used in the treatment of relapsed or refractory peripheral T cell lymphoma.
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