Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 5,6-dihydro-9,10-dimethoxy-d6-benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium, monochloride
Purity: ≥99% deuterated forms (d1-d6)
Formula Markup: C20H12D6NO4 / Cl
Formula Weight: 377.85032
Notes: Berberine-d6 is intended for use as an internal standard for the quantification of berberine (Item No. 10006427) by GC- or LC-MS. Berberine is an isoquinoline alkaloid that has been found in C. fenestratum and has diverse biological activities.{57563,25000,37022,49318,12390} It induces frameshift mutations and gene crossovers in haploid and diploid strains of S. cerevisiae, respectively, in the exponential growth phase when used at a concentration of 50 µg/ml.{25000} Berberine is active against the S. aureus strains ATCC 25922 and NCTC 8530 (MIC = 250 µg/ml for both).{37022} It decreases contusion volume, ventricle enlargement, and neurological deficits in a mouse model of controlled cortical impact-induced traumatic brain injury (TBI) when administered at a dose of 10 mg/kg.{49318} Berberine (50 mg/kg) reduces serum LDL cholesterol levels in hamsters fed a high-fat high-cholesterol diet.{12390}
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